Synthesis, Anticancer Activity and Carbonic Anhydrase Inhibitory Activity of new Thiadiazole-hydrazone Derivatives

In five steps, new compounds 5a, 5b of thiadiazole-hydrazone derivatives were synthesized. Various spectral methods, such as 1H NMR, 13C and elemental analyses, used to clarify the structures compounds. Three cancer cell lines (MCF7, MDA, HT-29) one healthy line (L929) tested for cytotoxicity activity synthetic compounds, well their inhibitory action against carbonic anhydrase I II isoenzymes (hCA hCA II). Among them, compound exhibited remarkable CA activities compared a standard inhibitor with IC50 values at 27 µM 33,46 II. The have been found be ineffective lines. Furthermore, non-toxic line.